Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Category: Research
01 March 2021

Pooled CRISPR perturbation screens with multimodal RNA and protein single-cell profiling readout (Perturb-CITE-seq) applied to patient-derived melanoma and tumor-infiltrating lymphocyte co-cultures identifies new tumor immune evasion mechanisms. 

Chris J. Frangieh, Johannes C. Melms et al.

Nature Genetics, 1-10