Tumour gene expression signature in primary melanoma predicts long-term outcomes

Category: Research
18 February 2021 | Open Access

The identification of prognostic biomarkers can help stratify cancer patients. Here, the authors apply deep RNA sequencing from primary melanomas coupled with long-term clinical outcome data from a prospective multicentre phase III trial, to develop and validate a 121 metastasis-associated gene signature identifying early-stage melanoma patients at higher risk of metastasis and worse survival.

Manik Garg, Dominique-Laurent Couturier et al.

Nature Communications 12, 1137

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